REVIEW: POTENSI EKSTRAK KAYU SECANG (Caesalpinia sappan L.) SEBAGAI ANTIDIABETES MELLITUS
A REVIEW: THE POTENSIAL OF EXTRACT SECANG (Caesalpinia sappan L.) AS ANTIDIABETIC MELLITUS
Abstract
Diabetes mellitus is an acute metabolic disorder with several causes with symptoms such as high blood sugar volume accompanied by disorders of carbohydrate, lipid and protein metabolism as a result of insulin function insufficiency. The use of synthetic hypoglycemic chemical drugs can cause some side effects and require relatively expensive costs, so traditional herbal medicine is preferred because it has less side effects and lower costs. Plants that can be used as traditional medicine are secang wood plants (Caesalpinia sappan L). Based on literature studies, compounds contained in the stem or wood part of secang contain flavonoid, tannins, gallic acid, resins, brasilein, α-phellandrene, oscimene, essential oils, resorcinol, and brasilin. It is known that tannic acid (tannins) has antioxidant activity and has an antidiabetic mellitus effects and the brazilin content of secang wood plays a very important role in reducing blood sugar levels. brazilin has three mechanisms of action in reducing blood sugar levels, namely reducing oxidative stress, inhibiting intestinal mucosa GLUT 2, and inhibiting phosphodiesterase. The antihyperglycemic activity of brazilin helps insulin work in the absorption of glucose from the bloodstream into adipose cells by increasing the translocation of glucose transport especially GLUT4. This shows that the extract from the secang wood plant has the potential as an antidiabetic mellitus.
Keywords: Antidiabetic mellitus; Antioxidant; Hyperglycemic; Secang wood
References
Arisman. 2010. Obesitas, diabetes mellitus & dislipidemia. Jakarta: Buku Kedokteran EGC.
Kemenkes RI. 2014. Situasi dan Analisis Diabetes. INFODATIN: Pusat Data Dan Informasi Kementerian Kesehatan Republik Indonesia, 1 (Waspada Diabetes), 8.
International Diabetes Federation. 2017. IDF Diabetes Atlas – 8th Edition. International Diabetes Federation.
Dipiro, J. T., R. L. Talbert, G. C. Yee, G., Matzke, R., Welss B. G., dan Posey L. M. 2011. Pharmacotherapy: A Pathophysiologic Approach pp 1205, 1209-1211. New York: Mc Graw Hill Medical.
Putra, R.J.S., Achmad, A., Rachma, H. 2017. Kejadian Efek Samping Potensial Terapi Obat Anti Diabetes Pasien Diabetes Melitus Berdasarkan Algoritma Naranjo. Pharmaceutical Journal Of Indonesia. 2(2): 45-50
Farhana, H., Indra, T. M., dan Reza, A. K. 2015. Perbandingan Pengaruh Suhu dan Waktu Perebusan Terhadap Kandungan Brazilin Pada Kayu Secang (Caesalpinia Sappan L.). Bandung: UNISBA
Suiraoka. 2012. Penyakit Degeneratif. Yogyakarta: NuhaMedika.
Kemenkes RI. 2014. Profil Kesehatan Indonesia 2014. Jakarta: Kemenkes RI
Lemos, T. Nunes, S. Teixeira, F. Reis, F. 2011. Regular Physical Exercise Training Assists Inpreventing Type 2 Diabetes Development: Focuson its Antioxidant and Anti-inflammatory Properties. Cardio Vascular Diabetelogy. Volume 10. Nomor 12. 2011: 1-15.
International Diabetes Federation. 2017. IDF Diabetes Atlas Eighth Edition 2017. Brussel: International Diabetes Federation.
American Diabetes Association. 2018. Standards of Medical Care In Diabetes-2018. USA: Diabetes Care.
Tahrani, A. A., A. H. Barnett, dan C. J. Bailey. 2016. Pharmacology and Therapeutic Implications of Current Drugs for Type 2 Diabetes mellitus. Nature Publishing Group. 12(10): 566-592.
Wells, B. G., J. T. DiPiro, C. V. DiPiro, dan T. L. Schwinghammer. 2015. Pharmacotherapy Handbook Ninth Edition. USA: McGraw-Hill Education.
Fatimah, R. N. 2015. Diabetes mellitus Tipe 2. Lampung: Universitas Lampung. 4, 93–101.
Hanum, N. N. 2013. Hubungan Kadar Glukosa Darah Puasa dengan Profil Lipid pada Pasien Diabetes mellitus tipe 2 di Rumah Sakit Umum Daerah Cilegon periode Januari-April 2013. Jakarta: Universitas Islam Negeri Syarif Hidayatullah.
NIIDK. 2014. Causes of diabetes. Maryland: National Institure of Diabetes and Digestive and Kidney Diseases. 253(1718). 37.
Prabawati, R. K. 2012. Mekanisme Seluler dan Molekular Resistensi Insulin. Malang: Universitas Brawijaya. 1, 1– 15.
Ramadhan, N., Marissa, N. 2015. Karakteristik Penderita Diabetes Mellitus Tipe 2 Berdasarkan Kadar HBA1C di Puskesmas Jayabaru Kota Banda Aceh. Aceh: Loka Penelitian dan Pengembangan Biomedis Aceh.
DeFronzo, R. A. 2010. Pathogenesis of Type 2 Diabetes: Metabolic and Molecular Implications for Identifying Diabetes Genes. Diabetes Review. USA: University of Texas Health Science Center. 177-269.
Cornell, S. 2015. Continual Evolution of Type 2 Diabetes: An Update On Pathophysiology and Emerging Treatment Options. Therapeutics and Clinical Risk Management. 2015:621.
Mohamed, J. 2016. Mechanism of Diabetes-Induced Liver Damaged, The Role of Oxidative Stress and Inflammation. SQU Medical Journal. 16(2): 132-141.
Appel, L. J., Wright, J. T., Greene, T., Agodoa, L. Y., Astor, B. C., Bakris, G. L., et al. 2010. Intensive Blood-Pressure Control in Hypertensive Chronic Kidney Disease. The New England Journal of Medicine. 363: 918-29.
Inzucchi, S. E., Bergenstal, M. R., Buse, J. B., Diamant, M., Ferrannini, E., Nauck, M. et al. 2012. POSITION STATEMENT Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the Studyof Diabetes (EASD). Diabetologia. 1577-1596.
Sari, R., dan Suhartati. 2016. Secang (Caesalpinia Sappan L.): Tumbuhan Herbal Kaya Antioksidan. Makassar: Balai Litbang Lingkungan Hidup dan Kehutanan Makassar. 13(1): 57-67
Padmaningrum, R.T., Marwati, S., & Wiyarsi, A. 2012. Karakter ekstrak zat warna kayu secang (Caesalpinia sappan L) sebagai indikator titrasi asam. 2007. 1–9.
Hidayat, Syamsul, Rodame & Napitupulu. 2015. Kitab Tumbuhan Obat. Jakarta: Agriflo.
Siwi, A. A. N. 2015. Analisa Zat Warna Merah Pada Ekstrak Kayu Secang (Caesalpinia Sappan L.) Menggunakan Spektrofotometer Visible. Semarang: Universitas Diponegoro.
Astina, I. G. A. 2010. Optimasi Pembuatan Ekstrak Etanolik Kayu Secang (Caesalpinia sappan L.) secara Digesti [Skripsi]. Yogyakarta: Universitas Sanata Dharma.
Syifa, T. 2015. Resep Wedang Uwuh Khas Yogyakarta Yang Menyehatkan. http://www.butania.com/2015/11/resep-wedang-uwuh.html
Jun H., Xiaoling Y., Wei W., Hao W., Lei H., Lijun D. 2008. Antioxidant activity in vitro of three constituents from caesalpinia. Tsinghua Science and Technology. 13(4): 474-479.
Fuke, C., Yamahara, J., Shimokawa, T., Kinjo, J., Tomimatsu, T., Nohara, T. 1985. Two aromatic compounds related to brazilin from Caesalpinia sappan. Phytochemistry. 24: 2403-2406.
Yemirta. 2010. Identifikasi Kandungan Senyawa Antioksidan Dalam Kayu Secang (Caesalpinia Sappan). Jurnal Kimia dan Kemasan. 32(2): 41-46
Fu, L., Huang X., Lai Z., Hu Y., Liu H., Cai X. 2008. A New 3-Benzylchroman Derivate from Sappan Lignum (Caesalpinia Sappan). Molecules. 13(8): 1923-1930.
Nagai, M., Nagumo, S. 1986. Protosappanin B, a new dibenzoxocin derivative from sappan lignum (Caesalpinia sappan). Heterocycles 24: 601-606.
Kim, D. S., Baek, N. I., Oh, S. R., Jung, K. Y., Lee, I. S., Lee, H. K. 1997. NMR assigment of brazilin. Phytochemistry 46: 177-178.
Miyahara, K., Kawasaki, T., Kinojo, J. E., Shimokawa, T., Yamahara, J., Yamasaki, M. 1986. The X-ray analysis of caesalpin J from sappan lignum. Chem. Pharm. Bull. 34: 4166-4169.
Sugiyanto, R. N., Putri, S. R., Damanik, F. S., Sasmita, G. M. A. 2013. Aplikasi kayu secang (Caesalpinia sappan L.) dalam upaya prevensi kerusakan DNA akibat paparan zat potensial karsinogenik melalui MNPCE assay. Yogyakarta: Universitas Gadjah Mada.
Zanin, J. L. B., De Carvalho, B. A., Martinelli, P. S., Santos, M. H. D., Lago, J. H. G., Sartorelli, P., Viegas, C., dan Soares, M. G. 2012. The genus Caesalpinia L. (Caesalpiniaceae): phytochemical and pharmacological characteristics. Molecules. 17(7): 7887-7902.
Nirmal, N. P., Rajput, M. S., Prasad, R. G. S. V., dan Ahmad, M. 2015. Brazilin from Caesalpinia sappan heartwood and its pharmacological activities: A review. Asian Pacific Journal of Tropical Medicine. 8(6): 421–430.
Gomes, C. B. D. S., Elisangela, Jimenez, G. C., Silva, L. C. N. D. Sá F. B. D., Souza, K. P. C. D., Paiva, G. S., Souza, I. A. D. 2014. Evaluation of Antioxidant and Antiangiogenic Properties of Caesalpinia Echinata Extracts. Journal of Cancer 5(1): 143-150.
Sugiyanto, R. N. 2011. Paparan zat potensial karsiogenik melalui MNPCE ASSAY Kayu Secang (Caesalpinia Sappan L) dalam Upaya Prevensi Kerusakan DNA. Yogyakarta: Universitas Gadjah Mada
Rina, O. 2013. Identifikasi Senyawa Aktif dalam Ekstrak Etanol Kayu Secang (Caesalpinia sappan. L.). Lampung: Universitas Lampung. 215–218.
Sufiana dan Harlia. 2014. Uji aktivitas antioksidan dan sitotoksisitas campuran ekstrak metanol kayu sepang (Caesalpinia sappan L.) dan kulit kayu manis (Cinnamomum burmanii B.). JKK. 3(2): 50 - 55.
Widowati, W. 2011. Uji fitokimia dan potensi antioksidan ekstrak etanol kayu secang (Caesalpinia sappan L.). Jurnal Kedokteran Maranatha. 11(1): 23 – 31.
Padmaningrum, R. T., Siti, M., dan Antuni, W. 2012. Karakter ekstrak zat warna kayu secang (Caesalpinia sappan L.) sebagai indikator titrasi asam basa. Yogyakarta: Universitas Negeri Yogyakarta.
Lioe, H. N., Adawiyah, D. R., dan Anggraeni, R. 2012. Isolation and characterization of the major natural dyestuff component of Brazilwood (Caesalpinia sappan L.). International Food Research Journal. 19(2): 537-542.
Batubara, I., Mitsunaga, T. & Ohashi, H. 2010. Brazilin from Caesalpinia sappan Wood as an Antiacne Agent. J. Wood. Sci. 56: 77-81.
Jumara, W. 2018. Pengaruh Kondisi pH dan Perbandingan Rempah Terhadap Karakteristik Minuman Serbuk Secang (Caesalpinia Sappan L.). Bandung: Universitas Pasundan.
Indariani S. 2011. Aktivitas antihiperglikemik minuman fungsional berbasis ekstrak daun kumis kucing (Orthosiphon Aristatus BI. Miq) pada mencit hiperglikemik yang diinduksi dengan streptozotocin. [Tesis]. Bogor: Institut Pertanian Bogor.
Diana. 2010. Aktivitas anti-hiperglikemik dari minuman fungsional berbasis kumis kucing (Orthosiphon aristatus BI. Miq) secara in vitro dan ex vivo. [Skripsi]. Bogor: Institut Pertanian Bogor.
Cai Y, Luo Q, Sun M, Corke H. 2004. Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Science. 4: 2157-2184.
Swatriani, L. 2012. Pemberian Ekstrak Kayu Secang (Caesalpinia Sappan) Secara Oral Menurunkan Kadar Glukosa Sewaktu Pada Tikus Diabetes mellitus. [Disertasi]. Bali: Universitas Udayana.
Stuart. 2011. Medicine Philipine. Stuartxchange.com/sapan.html. Diakses pada tanggal 25 oktober 2020.
Lestari N. P., Tjandrakirana., Kuswanti N., 2013. Pengaruh Pemberian Campuran Cairan Rebusan Secang (Caesalpinia sappan L.) dan Daun Lidah Buaya (Aloe vera) terhadap kadar glukosa darah mencit (Mus musculus). Surabaya: Universitas Negeri Surabaya. 2(1): 113-119.
Li WL, Zheng HC, Bukuru J, De Kimpeb N. 2004. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of Ethnopharmacology. 92: 1–21.
Sa’pang, M. 2015. Efek Antihiperglikemik Minuman Secang (Caesalpinia sappan Linn.) Pada Wanita Dewasa Dengan Pradiabetes. [Tesis]. Bogor: Institut Pertanian Bogor.
Febriyenti, N. Suharti, H. Lucida, E. Husni, dan O. Sedona. 2018. Karakterisasi dan Studi Aktivitas Antioksidan Dari Ekstrak Etanol Secang (Caesalpinia Sappan L.). Jurnal Sains Farmasi dan Klinis. 5(1):23-27
Zhong, X., Wu, B., pan, Y. J., and Zheng, S. 2009. Brazilein Inhibits Survivin Protein and Mrna Expression and Induces Apoptosis in Hepatocellular Carcinoma HepG2 cells. Neoplasma, 56 (5): 87 - 92.
Rusdi, U. D., W. Widowati, dan E. T. Marlina. 2005. Efek ekstrak kayu secang, vitamin E dan vitamin C terhadap Status Antioksidan Total (SAT) pada mencit yang terpapar aflatoksin. Media Kedokteran Hewan. 21 (2): 66 - 68.
Rahmawati, F. 2011. Kajian potensi ‘wedang uwuh’ sebagai minuman fungsional. Yogyakarta: Universitas Negeri Yogyakarta.
Yusuf, M. 2019. Efek Infus Kayu Secang (Caesalpinia sappan L.) Terhadap Penurunan Kadar Gula Darah Mencit (Mus musculus). Makasar: Universitas Megarezky.
Khil L. Y., Han S. S., Kim S. G., Chang T. S., Jeon S. D., So D. S., Moon C. K. 1999. Effects of brazilin on GLUT4 recruitment in isolated rat epididymal adipocytes. Biochem Pharmacol. 58: 1705–1712.
You E. J., Khil L. Y., Kwak W. J., Won H. S., Chae S. H., Lee B. H., Moon C. K. 2005. Effects of brazilin on the production of fructose-2,6-bisphosphate in rat hepatocytes. Ethnopharmacol. 102(1): 53-57.
Harvey R. A., Ferrier D. R. 2011. Lippincott’s illustrated reviews: Biochemistry 5th ed. Philadelphia (USA): Wolters Kluwer Health.
Subramanian, R., Asmawi, M. Z., Sadikun, A. 2010. In vitro alpha-glucosidase and alpha-amylase enzyme inhibitory effect of Andrographis paniculata extract and andrographolide. Acta, j. Biochem. 55(2):391-398
Singh A., T. K. Bhat, dan O. P. Sharma. 2011. Clinical Biochemistry of Hepatotoxicity. Clinical Toxicology.
Siregar I. P. A. 2019. Pengaruh Pemberian Ekstrak Kayu Secang (Caesalpinia Sappan L.) Terhadap Kadar SGOT dan SGPT Darah Tikus Diabetes yang Diinduksi Aloksan. [Skripsi]. Jember: Universitas Jember
Won H. S., Lee J, Khil L. Y., Chae S. H., Ahn M. Y., Lee B. H., Chung J. H., Kim Y. C., Moon C. K. 2004. Mechanism of action of brazilin on gluconeogenesis in isolated rat hepatocytes. Planta Med. 70:740–744.
Utama, I. H., Arjentinia I P. G. Y. 2014. Ekspresi Glukosa Transporter 4 (GLUT 4) Pada Berbagai Organ Tikus Hiperglikemia. Bali: Universitas Udayana.
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