Eksplorasi Senyawa Alkaloid Carbazole Murraya microphylla sebagai Antikanker Inhibitor SIRT1 dan CDK9: Studi In Silico
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Kanker saat ini menjadi masalah kesehatan utama karena jumlah kematian dan prevalensinya yang meningkat secara signifikan, salah satunya kanker payudara dan kanker serviks. Pengembangan obat baru menjadi upaya utama untuk mengatasi risiko kanker. Senyawa bahan alam merupakan sumber utama penemuan senyawa obat yang diyakini memiliki toksisitas yang lebih rendah dibandingkan obat sintetis. Penelitian ini bertujuan untuk mengungkap aktivitas antikanker dari senyawa alkaloid carbazole Murraya microphylla sebagai inhibitor SIRT1 dan CDK9 secara in silico. Berdasarkan hasil simulasi molecular docking, diperoleh senyawa isomahanimbine dan mahanimbine sebagai inhibitor SIRT1, dan senyawa girinimbine dan koenigine sebagai inhibitor CDK9 dengan nilai binding energy yang lebih rendah dari inhibitor kontrol, yang menunjukkan bahwa senyawa-senyawa tersebut berpotensi sebagai antikanker. Prediksi sifat fisikokimia, drug-likeness dan farmakokinetik keempat senyawa tersebut menunjukkan hasil yang baik dan memenuhi kriteria senyawa obat. Penelitian lebih lanjut diperlukan untuk mengungkap potensi senyawa-senyawa tersebut sebagai obat antikanker.
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