Sintesis dan Karakterisasi Nanoenkapsulasi Sambiloto (Andrographis paniculata) Berbasis Karboksimetil Kitosan
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Penelitian ini bertujuan untuk mensintesis dan mengkarakterisasi nanoenkapsulasi ekstrak sambiloto (Andrographis paniculata) berbasis karboksimetil kitosan guna meningkatkan bioavailabilitas senyawa bioaktif. Ekstrak sambiloto diperoleh melalui maserasi menggunakan metanol dan dienkapsulasi dengan karboksimetil kitosan menggunakan metode ultrasonikasi. Hasil karakterisasi menggunakan Particle Size Analyzer menunjukkan ukuran partikel sebesar 492,19 nm dengan indeks polidispersitas (PDI) 0,3464 sehingga telah memenuhi kriteria nanopartikel yang baik dalam sistem penghantaran obat. Uji stabilitas pH menunjukkan bahwa nanoenkapsulasi sambiloto memiliki stabilitas yang relatif baik. Hal tersebut menunjukkan bahwa nanoenkapsulasi berbasis karboksimetil kitosan berpotensi dalam melindungi senyawa bioaktif dalam sistem pencernaan.
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