Sintesis Enkapsulasi Ekstrak Kunyit (Cursuma longa. L) Berbasis Karboksimetil Kitosan sebagai Penghantaran Obat indonesia
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Kurkumin merupakan senyawa bioaktif utama dalam kunyit (Curcuma longa L.) yang memiliki aktivitas antioksidan tinggi, namun penggunaannya terbatas akibat kelarutan rendah dan stabilitas yang buruk pada kondisi fisiologis. Penelitian ini bertujuan untuk mensintesis dan mengkarakterisasi nanopartikel enkapsulasi kurkumin berbasis karboksimetil kitosan (Cur-NPs) sebagai sistem penghantaran obat yang lebih stabil. Sintesis dilakukan menggunakan metode sonikasi, sedangkan karakterisasi meliputi analisis PSA dan uji stabilitas pH. Hasil menunjukkan bahwa Cur-NPs memiliki ukuran partikel sebesar 281,3 nm dan PDI 0,3897, menandakan distribusi partikel yang homogen. Cur-NPs menunjukkan stabilitas yang lebih baik dibandingkan ekstrak kunyit pada berbagai pH (2-10). Hasil ini menunjukkan bahwa enkapsulasi menggunakan CMC mampu meningkatkan stabilitas dan efisiensi pelepasan kurkumin dalam sistem biologis.
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