SINTESIS DAN KARAKTERISASI HIDROGEL KITOSAN-LIDAH BUAYA (Aloe vera)-LENDIR BEKICOT (Achatina fulica)
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Hidrogel merupakan sediaan topikal yang dirancang lebih praktis dalam mendukung proses penyembuhan luka lebih cepat. Hidrogel harus mempunyai karakteristik seperti biokompatibel, tidak beracun, sensitif terhadap lingkungan fisiologis, serta fleksibilitas yang baik. Karakter tersebut membuka peluang hidrogel dapat diaplikasikan di biomedis dengan kombinasi bahan-bahan yang memiliki efek sinergis. Penelitian ini dilakukan untuk mensintesis hidrogel dengan mengkombinasikan kitosan, lidah buaya, dan lendir bekicot. Pada penelitian ini, dilakukan sintesis hidrogel dengan variasi penambahan lidah buaya sebesar 5%, 10%, dan 15% (b/b) yang kemudian dilakukan karakterisasi secara fisika dan kimia. Hasil penelitian menunjukkan semakin banyak penambahan lidah buaya maka meningkatkan daya sebarnya dan menurunkan daya lekat dari hidrogel. Dengan hasil uji karakterisasi uji daya sebar pada rentang 5,07 – 5,34 cm dan uji daya lekat 16 – 44 detik.
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Referensi
[1] L. Martinengo, M. Olsoon, R. Bajpai, M. Soljak, Z. Upton, A. Schmidtchen, J. Car and K. Jarbrink, "Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies," Annals of Epidemiology, vol. 29, pp. 8-15, 2019.
[2] X. Zhu, M. Olsson, R. Bajpai, K. Jarbrink, W. E. Tang and J. Car, "Health-related quality of life and chronic wound characteristics among patient with chronic wounds treated in primary care: A cross-sectional study in Singapore," International Wound Journal, vol. 19, no. 5, pp. 1121-1132, 2022.
[3] D. Rahayuningdyah, D. Lyrawati and F. Widodo, "Pengembangan Formula Hidrogel Balutan Luka Menggunakan Kombinasi Polimer Galaktomanan dan PVP," Pharmaceutical Journal of Indonesia, vol. 5, no. 2, pp. 117-122, 2020.
[4] H. J. Edy, M. Marchaban, S. Wahyuono and A. E. Nugroho, "Formulasi dan Uji Sterilisasi Hidrogel Herbal EKstrak Daun Tagetes erecta L.," Pharmacin, vol. 5, no. 2, pp. 9-16, 2016.
[5] J. Basso, A. Miranda, S. Nunes, T. Cova, J. Sousa, C. Vitorino and A. Pais, "Hydrogel-Based Drug Delivery Nanosystem For The Treatment of Brain Tumors," Gels, vol. 4, no. 3, p. 62, 2018.
[6] H. Liu, C. Wang, C. Li, Y. Qin, Z. Wang, F. Yang, Z. Li and J. Wang, "A Functional Chitosan-Based Hydrogel As A Wound Dressing And Drug Delivery System in The Treatment Of Wound Healing," Royal Society of Chemistry Advances, vol. 8, no. 13, pp. 7533-7549, 2018.
[7] A. H. Yilmaz, "Antibacterial activity of chitosan-based systems," in In Functional Chitosan: Drug Delivery and Biomedical Applications, 2019, pp. 457-489.
[8] M. Rashad, S. Sampò, A. Cataldi and S. Zara, "Biological activities of gastropods secretions: Snail and slug slime," Natural Products and Bioprospecting, vol. 13, no. 1, p. 42, 2023.
[9] S. D. Sulisetyawati and M. Oktariani, "Perbandingan efektivitas lendir bekicot (Achatina fulica) dengan kitosan terhadap penyembuhan luka," Jurnal Kesehatan Kusuma Husada, pp. 104-110, 2015.
[10] A. Y. Sianipar, A. Prayoga and A. Y. Nainggolan, "Activity of a gel combination of Aloe vera (Aloe vera (L.) Burm.f.) and snail mucus (Achatina fulica (Ferussac, 1821)) on burn wounds in male white rats (Rattus norvegicus) Wistar strains.," Indonesian Journal of Pharmaceutical Education (e-Journal), vol. 3, no. 2, pp. 186-194, 2023.
[11] M. H. Radha and N. P. Laxmipriya, "Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review.," Journal of Traditional and Complementary Medicine, vol. 5, no. 1, pp. 21-26, 2015.
[12] C. E. Matei, A. I. Visan and R. Cristescu, "Aloe vera polysaccharides as therapeutic agents: Benefits versus side effects in biomedical applications.," Polysaccharides, vol. 6, no. 2, p. 36, 2025.
[13] R. A. Rahadian, C. D. Mambo, E. Nangoy, Fatimawali, A. S. Masengi and J. Posangi, "Uji antiinflamasi ekstrak etanol lidah buaya (Aloe vera (L.) Burm. F.) dengan metode stabilisasi membran sel darah merah in vitro," Jurnal Locus: Penelitian & Pengabdian, vol. 4, no. 2, pp. 1179-1192, 2025.
[14] T. &. C. S. E. Astuti, "Synthesis and characterization of chitosan-nano silver-Aloe vera as wound gel preparation and antibacterial activity test of Staphylococcus aureus," Indonesian Journal of Chemical Science, vol. 13, no. 1, pp. 43-51, 2024.
[15] M. Saberian, E. Sayedjafari, S. J. Zargar, F. M. Mahdavi and P. Sanaei-rad, "Fabrication and characterization of alginate/chitosan hydrogel combined with honey and aloe vera for wound dressing applications," Journal of Applied Polymer Science, no. e51398, 2021.
[16] P. Riantikasari and I. Maesaroh, "Stabilitas dan uji keamanan lendir bekicot (Achatina fulica) dalam formulasi sediaan sheet mask," Medical Sains: Jurnal Ilmiah Kefarmasian, vol. 8, no. 1, pp. 1-10, 2023.
[17] S. Lokhande, S. Mankar, A. Satpute and M. Jadhao, "Formulation and evaluation of polyherbal peel off mask," Asian Journal of Pharmaceutical Research and Development, vol. 12, no. 3, pp. 23-28, 2024.
[18] N. Aprilianti, H. Hajrah and Y. Sastyarina, "Optimasi polivinilalkohol (PVA) sebagai basis sediaan gel antijerawat," Proceeding of Mulawarman Pharmaceuticals Conferences, vol. 11, no. 1, pp. 17-21, 2020.
[19] L. Fitriyah and S. E. Cahyaningrum, "Synthesis and Characterization of Gel Chitosan-Nanosilver Extract of Pare Fruit (Momordica charantia) as Antibacteria Against Staphylococcus aureus," Indonesian Journal of Chemical Science, pp. 82-93, 2023.
[20] A. Yusuf, E. Nurawaliah and N. Harun, "Uji Efektivitas Gel Ekstrak Etanol Daun Kelor (Moringa oleifera L.) sebagai Antijamur Malassezia furfur," Kartika: Jurnal Ilmiah Farmasi, vol. 5, no. 2, pp. 62-67, 2017.
[21] S. T. Pramesti, Khabibi and N. B. A. Prasetya, "Pemanfaatan Kitosan Termodifikasi Asam Askorbat sebagai Adsorben Ion Logam Besi(III) dan Kromium(III)," Jurnal Kimia Sains dan Aplikasi, vol. 15, no. 2, pp. 70-75, 2012.
[22] Y. P. Tanjung and A. M. Rokaeti, "Formulasi dan evaluasi fisik masker wajah gel peel off ekstrak kulit buah naga merah (Hylocereus polyrhizus)," Majalah Farmasetika, vol. 4, no. 1, pp. 157-166, 2019.
[23] V. Goodship and D. K. Jacobs, Polyvinyl alcohol: Materials, processing and applications (Rapra Review Reports, Vol. 16, No. 12), Shrewsbury, Shropshire: Smithers Rapra Technology, 2009.
[24] A. D. Dantas, M. F. Oliveira, J. A. Silva and L. P. Souza, "Effects of xanthan gum on texture and stability of various food products," Journal of Texture Studies, vol. 51, no. 3, pp. 400-415, 2020.
[25] X. N. Du, Y. He, Y. W. Chen, Q. Liu, L. Sun, H. M. Sun, X. F. Wu and Y. Lu, "Decoding Cosmetic Complexities: A Comprehensive Guide to Matrix Composition and Pretreatment Technology," Molecules, vol. 29, no. 2, p. 411, 2024.
[26] I. Setiani and N. C. Endriyanto, "Formulasi Gel Ekstrak Buah Tomat (Solanum lycopersicum L.) dengan Variasi Konsentrasi HPMC serta Uji Fisiknya," Indonesian Journal of Pharmaceutical Education (e-Journal), vol. 3, no. 3, pp. 378-390, 2023.
[27] S. Rohmani and M. A. A. Kuncoro, "Uji Stabilitas dan Aktivitas Gel Handsanitizar Ekstrak Daun Kemangi," Journal of Pharmaceutical Science and Clinical Research, vol. 1, pp. 16-28, 2019.
[28] Rahmaniah, E. Isdar and S. Rani, "Sintesis Dan Karakterisasi Kitosan Berbasis Cangkang Landak Laut Sebagai Kandidat Absorban Logam Berat," Journal Online of Physics, vol. 9, no. 2, pp. 30-36, 2024.
[29] N. I. Rasli, H. Basri and Z. Harun, "Zinc oxide from aloe vera extract: Two-level factorial screening of biosynthesis parameters," Heliyon, vol. 6, no. 1, p. e03156, 2020.
[30] A. B. D. Nandiyanto, R. Oktiani and R. Ragadhita, "How to read and interpret FTIR spectroscope of organic material," Indonesian Journal of Science and Technology, vol. 4, no. 1, pp. 97-118, 2019.
[31] U. R. Purwanto and E. D. Ikasari, "Uji Aktivitas Antibakteri Sediaan Sprayable Hidrogel Yang Mengandung Lendir Bekicot (Achatina fulica) Terhadap Staphylococcus aureus," Cendekia Journal of Pharmacy, vol. 8, no. 1, pp. 41-50, 2024.
[32] U. Sadiq, H. Gill and J. Chandrapala, "Ultrasound-Assisted Encapsulation of Anthraquinones Extracted from Aloe-Vera Plant into Casein Micelles," Gels, vol. 8, no. 9, p. 597, 2022.