OPTIMIZATION OF TWEEN 80 CONCENTRATION IN NANOEMULSION FORMULATION OF COMBINED PEGAGAN AND KELOR LEAF EXTRACTS
Main Article Content
Abstract
Abstract. This study aims to optimize the nanoemulsion formulation of combined extracts of Centella asiatica and Moringa oleifera leaves using varying concentrations of Tween 80 as a surfactant. Three formulas were prepared with 8%, 10%, and 12% Tween 80. Physical evaluations included particle size, pH, and viscosity. Results showed that increasing Tween 80 concentration increased particle size and viscosity, while pH remained relatively stable. The 8% Tween 80 formula yielded the most optimal result with the smallest particle size and suitable viscosity for topical application. One-way ANOVA revealed significant differences in particle size and viscosity, but not in pH. These findings indicate that Tween 80 concentration affects the physical stability of the nanoemulsion
Key words: kelor leaves, pegagan leaves, nanoemulsion, tween 80
Downloads
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
References
[1] N. S. Daud, M. Musdalipah, and A. Lamadari, "Formulasi Nanoemulsi Aspirin Menggunakan Etanol 96 % Sebagai Ko-Surfaktan," Warta Farmasi, vol. 6, no. 1, pp. 1–11, 2017.
[2] D. D. R. Ayuningtias, D. Nurahmanto, and V. A. Rosyidi, "Optimasi komposisi polietilen glikol dan lesitin sebagai kombinasi surfaktan pada sediaan nanoemulsi kafein," E-Jurnal Pustaka Kesehatan, vol. 5, no. 1, pp. 157–163, 2017.
[3] M. Hanifah and M. Jufri, "Formulation and Stability Testing of Nanoemulsion Lotion Containing Centella asiatica Extract," J. Young Pharm., vol. 10, no. 4, pp. 404–408, 2018.
[4] B. Brinkhaus, M. Lindner, D. Schuppan, and E. G. Hahn, "Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica," Phytomedicine, vol. 7, no. 5, pp. 427–448, 2020.
[5] R. Ceci, M. Maldini, P. La Rosa, L. Sireno, C. Antinozzi, M. E. Olson, I. Dimauro, and G. Duranti, "Efek Ekstrak Daun Kelor (Moringa oleifera) terhadap Proliferasi Mioblas C2C12 dan Status Redoks pada Inflamasi Oksidatif," Antioxidants, vol. 13, no. 1460, 2024.
[6] P. V. Y. Yamlean, "Formulasi Dan Uji Antibakteri Sediaan Sabun Cair Ekstrak Daun Kemangi (Ocymum Basilicum L.) Terhadap Bakteri Staphylococcus Aureus," Pharmacon, vol. 6, no. 1, pp. 76–86, 2017.
[7] A. N. F. Ahmadita, "Formulasi Losion Ekstrak Etanol 70% Herba Kemangi (Ocimum americanum L.) Menggunakan Asam Stearat Sebagai Emulgator," Skripsi, Program Studi S1 Farmasi, Universitas Islam Negri Syarif Hidayatullah, Jakarta, 2017.
[8] N. Ariani, D. R. Febrianti, and R. Niah, "Uji Aktivitas Ekstrak Etanolik Daun Kemangi (Ocimum sanctum L.) terhadap Staphylococcus aureus secara In Vitro," Jurnal Pharmascience, vol. 7, no. 1, pp. 107–115, 2020.
[9] A. Arianto and C. Cindy, "Preparation and Evaluation of Sunflower Oil Nanoemulsion as a Sunscreen," Herbal Medicine in Pharmaceutical and Clinical Sciences, vol. 7, no. 22, pp. 3757–3761, 2019.
[10] D. N. K. Rahmaniyah, "Perbandingan Formula Sistem Nanoemulsi dan Nanoemulsi Gel Hidrokortison Dengan Variasi Konsentrasi Fase Minyak Palm Oil," Skripsi, Program Studi S1 Farmasi, Universitas Islam Negeri Maulana Malik Ibrahim, Malang, 2018.
[11] E. Zulfa, D. Novianto, and D. Setiawan, "Formulasi Nanoemulsi Natrium Diklofenak dengan Variasi Kombinasi Tween 80 Dan Span 80: Kajian Karakteristik Fisik Sediaan," Media Farmasi Indonesia, vol. 14, no. 1, pp. 1471–1477, 2019.
[12] S. Kusuma, S. Mita, and A. Mutiara, "Antimicrobial lotion containing red Piper betle leaf (Piper crocatum Ruiz and Pav) ethanolic extract for topical application," National Journal of Physiology, Pharmacy and Pharmacology, vol. 8, pp. 130–138, 2017.
[13] I. Maharini, D. Utami, and F. Fitrianingsih, "The Influence of Tween 80 in the Formulations of Nanoemulsion Virgin Coconut Oil," in International Conference on Pharmaceutical Research and Practice, 2018, pp. 75–78.
[14] A. C. Adi, N. Setiawaty, A. Anindya, and H. Rachmawati, "Formulasi dan Karakterisasi Sediaan Vitamin A," Media Gizi Indonesia, vol. 14, no. 1, pp. 1–13, 2019.
[15] L. Winarti, R. Martien, Suwaldi, and L. Hakim, "An experimental design of SNEDDS template loaded with bovine serum albumin and optimization using D-optimal," International Journal of Pharmaceutical and Clinical Research, vol. 8, no. 5, pp. 425–432, 2016.
[16] M. H. C. Klau and R. J. Hesturini, "Effect of Ethanol Extract of Dandang Gendis Leaves (Clinacanthus nutans (Burm F) Lindau) on Analgesic Power and Stomach Macroscopic Appearance of Mice," J. Farmasi & Sains Indonesia, vol. 4, no. 1, pp. 6–12, 2021.
[17] Y. Ambari, A. O. Saputri, and I. H. Nurrosyidah, "Formulasi dan uji aktivitas antioksidan body lotion ekstrak etanol daun kemangi (Ocimum cannum Sims.) dengan metode DPPH (1, 1–Diphenyl-2-Picrylhydrazyl)," As-syifaa J. Farmasi, vol. 13, no. 2, pp. 86–96, 2021
[18] W. F. Qomara, I. Musfiroh, and R Wijayanti, “Review: Evaluasi Stabilitas dan Inkompatibilitas Sediaan Oral Liquid,” Majalah Farmasetika, vol. 8, no. 3, pp. 209–223, 2023.
[19] S. D. Amanda, "Pengaruh Variasi Konsentrasi Terhadap Uji Ph Dan Uji Viskositas Formulasi Sediaan Nanoemulgel Ekstrak Temu Kunci (Boesenbergia Rotunda)," Skripsi/Tesis/Disertasi, Universitas Islam Sultan Agung, Semarang, 2022.
[20] A. Setyopratiwi and H. T. U. Hanifah, "Formulasi dan Stabilitas Mikroemulsi Minyak dalam Air dengan Virgin Coconut Oil (VCO) Sebagai Fase Minyak Menggunakan Metode Emulsifikasi," in Prosiding Seminar Nasional Kimia 1, pp. 108–123, 2022.
[21] A. Fiyani, N. Saridewi, and S. Suryaningsih, “Analisis Konsep Kimia Terkait dengan Pembuatan Surfaktan dari Ampas Tebu,” Jurnal Riset Pendidikan Kimia (JRPK), vol., 10, no. 2, pp. 94–101, 2020.